Count in kits. Reach each tier one line at a time.

A kit is ten vials of one compound at one fill weight, and it is the smallest step the order list allows. That keeps every figure on the order a round number and every line a whole number of kits. When you plan quantities, plan them in kits first and convert to vials afterwards by adding a zero.

Working in kits also makes the tier thresholds easy to hold in your head. The three published breaks sit at 100 vials, 1,000 vials and 2,500 vials of a line, which is 10, 100 and 250 kits. A planner who thinks in kits sees at once that 99 kits is one short of the second break and that 250 kits lands exactly on the third. Kits are also how the order list counts each line, so what you planned and what you build read the same way.

An order must reach 100 vials, ten kits, before it can be submitted, and that total is taken across everything on it. One kit each of ten different compounds clears the minimum. Ten kits of one compound clears it just the same. Five kits of one line and five of another clears it too. The minimum asks only whether the order as a whole has reached ten kits, and it does not care how those kits are spread.

This is the only place on the sheet where lines are added together. It is worth being clear about that early, because the tier rule in the next section works the opposite way, and buyers who carry the pooling habit from the minimum into the tiers plan orders that do not reach the break they expected. The order list shows a running vial total and, while the order is below ten kits, states how many vials it is short.

Each compound reaches its price break on its own quantity. A line is one compound at one fill weight, and if a compound is stocked at three fill weights, those are three lines, each counted separately. The three breaks are 100 vials and above, 1,000 and above, and 2,500 and above, and a line sits in whichever band its own vial count falls into. Nothing else on the order moves it. The pricing page states the rule and shows a live example from the sheet.

Above the published table there is a fourth band. Once a single compound passes 10,000 vials, a thousand kits, the order summary replaces its total with a contract-pricing notice, which the desk quotes directly. That threshold is reached the same way as the others, on the quantity of that compound alone. Wholesale pricing explained goes through the reasoning behind the model; this guide stays with the counting.

Take 60 kits. Put all 60 on one compound and that line holds 600 vials, which is Tier 1, the 100-and-above band. Spread the same 60 kits as 20 kits each across three compounds and each line holds 200 vials, which is also Tier 1, three times over. Neither plan reaches the second break, and the total of 600 vials on the order never enters the calculation. The two orders differ only in how many lines they carry.

Now take 120 kits. All on one compound is 1,200 vials on one line, which is Tier 2. Split as 40 kits each across three compounds, each line holds 400 vials and each is Tier 1. The second plan has the same vial count as the first and reaches a lower band on every line. If the second break matters to you, the way to reach it is to concentrate kits on one line, not to add lines.

The tier boundary is the last case. Ninety-nine kits of one compound is 990 vials, ten short of the 1,000 break, and read literally that is a Tier 1 line. The rule on this sheet is that a smaller order never costs more than a larger one, so if 990 vials at the Tier 1 rate would come to more than 1,000 at the Tier 2 rate, the line is quoted at the Tier 2 figure. The order list applies that check on every line by itself. Even so, 100 kits is the cleaner plan.

For a compound stocked at more than one fill weight, the same mass of material arrives in a different number of vials depending on which fill you choose. One hundred kits of a 5 mg fill is 1,000 vials. The same mass of that compound at the 10 mg fill is 50 kits, 500 vials. The first plan is Tier 2 on its line; the second is Tier 1 on its own line, because the tier follows the vial count and not the mass in the cartons.

Each fill weight is a separate line, so 50 kits of the 5 mg fill and 50 kits of the 10 mg fill are two Tier 1 lines of 500 vials each, not one Tier 2 line of 1,000. When you choose a fill, you are choosing four things at once: the per-vial rate on the sheet, the tier the line will reach, the number of cartons on the truck and the number of vials to log and shelve.

As you add kits, the order list keeps a running vial total for the whole order and shows the three tier prices beside every line. When a line is within reach of its next break, the summary says how many more vials of that compound would get it there, with a single control that tops the line up. When a line is so close to a break that the boundary rule already applies, the summary says so instead.

Once the written quote arrives, it becomes the source for the purchase order. The PO should carry the quote reference; each line as the compound name on the sheet, its fill weight, the kit count and the vial count; the tier and per-vial figure the quote gave for that line; freight as quoted; the ship date the quote states; the ship-to address; and a note that a lot-specific certificate of analysis is requested. How to order covers what happens after the PO is raised.