Per vial, USD
| Fill weight | 100+ | 1,000+ | 2,500+ | Order |
|---|---|---|---|---|
| 5 mg | $10.00 | $8.40 | $8.20 | |
| 10 mg | $13.50 | $11.34 | $11.07 | |
| 20 mg | $25.00 | $21.00 | $20.50 |
Ordering at volume
Semaglutide is the fastest-moving line in this catalog and the one most likely to be quoted against a competing supplier, so a few things are worth knowing before you compare numbers. The per-vial price is dominated by active material rather than by vialing, which is not true of most of the shorter peptides here. That means the ladder from 5 mg to 20 mg tracks fill weight closely — a 20 mg vial does not cost four times a 5 mg vial, but it is much nearer to that than to parity. Buyers moving up a fill weight to reduce vial count usually find the saving smaller than expected.
Lead time is set by lyophilization scheduling rather than by synthesis. Freeze-drying runs in fixed chamber batches, so an order that fits an already-scheduled run ships in days while one that needs its own run waits for the next slot. Orders placed against the standing 1,000 and 2,500 vial breaks are usually the ones that fit a run, which is part of why the tier pricing exists at all — it reflects a real production economy, not just a volume discount.
Order across fill weights freely, but price them as separate lines: each fill weight reaches its own break on its own quantity, so 1,000 vials at 10 mg is Tier 2 on that line while 400 at 5 mg and 600 at 10 mg are two Tier 1 lines. Mixed orders draw from the same lot where the fill weights share one, and the certificate you receive names the specific lot shipped rather than a representative batch.
Specification
- Compound
- Semaglutide
- CAS number
- 910463-68-2
- Formula
- C₁₈₇H₂₉₁N₄₅O₅₉
- Molecular weight
- 4,113.6 g/mol
- PubChem CID
- 56843331
- Form
- Lyophilized powder, sealed vial
- Fill weights
- 5 mg · 10 mg · 20 mg
- Stock depth
- High-volume staples — Held deepest, quoted same day, shortest lead time.
- Intended use
- Laboratory research only. Not for human or veterinary use.
What the material is
Semaglutide is a synthetic analogue of human glucagon-like peptide-1, built on the GLP-1(7-37) backbone and modified at three positions. Alanine at position 8 is replaced with α-aminoisobutyric acid, which removes the dipeptidyl peptidase-4 cleavage site that makes the native peptide short-lived in solution. Lysine at position 34 is substituted with arginine so that acylation occurs at a single, predictable site.
That site is lysine 26, which carries an octadecanedioic acid chain attached through a γ-glutamate and two 8-amino-3,6-dioxaoctanoic acid spacer units. The C18 diacid is the reason the molecule is described as acylated, and the spacer is what separates that fatty chain from the peptide backbone. The result is a 4,113.6 g/mol molecule that behaves very differently in a buffer than the unmodified peptide it is derived from — it foams, it aggregates if mishandled, and it is far less soluble at low pH.
It ships as a white to off-white lyophilized cake under vacuum or inert headspace, sealed with a butyl stopper and an aluminium crimp. The cake should sit as an intact disc at the base of the vial; a collapsed or shrunken cake is a sign the lyophilization cycle or the seal has been compromised, and is worth photographing before you open the rest of a shipment.
Storage and reconstitution
Store the sealed vial at −20 °C, protected from light. Lyophilized peptide is stable for extended periods at that temperature; brief excursions to refrigerated or ambient conditions during transit are expected and do not compromise material that is still under seal and still presenting an intact cake.
The lyophilized cake dissolves readily in sterile water or an assay-appropriate buffer, and dissolves best when the solvent runs down the vial wall rather than onto the cake. Acylated peptides foam if shaken, and the air-liquid interface that creates encourages aggregation, so the vial is swirled rather than agitated. A correctly dissolved vial gives a clear, particle-free solution at room temperature within a minute or two.
Once in solution, hold at 2–8 °C and keep it out of light. Dissolved peptide has a much shorter working life than the lyophilized form, and repeated freeze-thaw cycling is the most common cause of degradation seen in returned material. Aliquot before freezing if the solution will be drawn on more than once.
Buying questions
What is the minimum order for wholesale semaglutide?
100 vials on the order — ten kits of ten — in any mix. Ten kits of semaglutide clears it, and so does one kit each of ten compounds. Reaching a PRICE TIER is separate: that depends on how many vials of semaglutide specifically you take.
How is the price per vial calculated at 1,000 and 2,500 vials?
On the quantity of that compound alone. Compounds do not pool toward a break, so 1,000 vials of semaglutide reaches Tier 2 on semaglutide whatever else is on the order. Fill weights of the same compound are quoted line by line at their own rate.
Is there a certificate of analysis for a bulk semaglutide order?
Yes, on request — every lot has one, and the COA page is where to ask. The certificate names the specific lot shipped rather than a representative batch, so it can be matched to the vials in front of you.
What is the lead time on a 2,500 vial order?
Lead time is driven by lyophilization batch scheduling rather than synthesis. Orders at the volume breaks generally fit an already-scheduled run; we confirm a date at quote rather than publishing a figure that would be wrong half the time.
Can I order semaglutide at more than one fill weight on the same purchase order?
Yes, and it is the normal case. 5, 10 and 20 mg vials can appear on one order and all of them count toward the same tier break.
