TB-500 — wholesale, research grade

Per vial, USD

How the three tiers work → Ordering FAQ → Reading the COA →

Ordering at volume

TB-500 is held as a high-volume line, so stock orders ship in days, but the per-vial economics run the other way from the short structural peptides it usually ships beside. Here the peptide is long and synthesis is the expensive part, so the 10 mg fill costs much nearer to twice the 5 mg fill than a short peptide would, and the vial itself is a small share of either. Moving up a fill weight saves on glass and freight, not on peptide.

Because the name is used loosely across the trade for both the full-length peptide and a fragment of it, the most important line on a purchase order for this compound is the identity specification. State the sequence or the mass you expect, and ask that the certificate report the observed mass. Lots are released against that certificate, and a mismatch between what a buyer meant and what the trade name means is the likeliest reason a first order of this compound would be queried.

Each fill weight is quoted as its own line and climbs the ladder on its own count. Large orders can draw on two lots where one lot cannot cover the quantity; both lots are then identified and the certificate for each is issued on request. Same-day written quotes are the norm for this line.

Specification

Compound

TB-500

CAS number

77591-33-4

Formula

C₂₁₂H₃₅₀N₅₆O₇₈S

Molecular weight

4,963.5 g/mol

PubChem CID

16132321

Form

Lyophilized powder, sealed vial

Fill weights

5 mg · 10 mg

Stock depth

High-volume staples — Held deepest, quoted same day, shortest lead time.

Intended use

Laboratory research only. Not for human or veterinary use.

What the material is

TB-500 is the catalog name for a synthetic peptide of the thymosin β4 family. The alias on the page reads "fragment", but the formula and mass listed for this line correspond to full-length thymosin β4 rather than to a shorter segment of it. The material is therefore supplied at a molecular weight consistent with full-length thymosin β4, and the sequence actually delivered is the one stated on the lot certificate. Buyers whose specification calls for a particular fragment should say so on the enquiry rather than relying on the trade name.

It is a long peptide by the standards of this catalog, and the catalog formula carries no lipid chain, which means the synthesis rather than the vial sets most of the cost. Physically it is a white to off-white lyophilized cake or fluffy powder in a crimp-sealed glass vial, and a long peptide like this tends to form a lighter, more open cake than the short ones do.

Storage and reconstitution

Frozen storage at −20 °C, dry and away from light, is the standard for the sealed vial and gives the longest shelf life. Refrigerated storage is acceptable when stock turns over within a few months. A vial that has warmed briefly in transit is not compromised provided the seal and the cake are intact.

A long peptide dissolves more slowly than a short one. Sterile water or a mild buffer goes down the side of the glass, and the vial stands and is then rotated gently rather than shaken, since a shaken solution of a large peptide foams and the foam is where aggregates form. Fully dissolved material is clear and colourless.

In solution the peptide has a limited working life. Refrigerate, keep dark, and portion out anything that will be frozen so that each portion is thawed only once. Cloudiness after storage indicates aggregation and the solution should not be relied on.

Buying questions